Ontology highlight
ABSTRACT:
SUBMITTER: Dulyaninova NG
PROVIDER: S-EPMC6004585 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Dulyaninova Natalya G NG Ruiz Penelope D PD Gamble Matthew J MJ Backer Jonathan M JM Bresnick Anne R AR
Molecular biology of the cell 20171227 5
S100A4, a member of the S100 family of Ca<sup>2+</sup>-binding proteins, is a key regulator of cell migration and invasion. Our previous studies showed that bone marrow-derived macrophages from S100A4<sup>-/-</sup> mice exhibit defects in directional motility and chemotaxis in vitro and reduced recruitment to sites of inflammation in vivo. We now show that the loss of S100A4 produces two mechanistically distinct phenotypes with regard to macrophage invasion: a defect in matrix degradation, due t ...[more]