Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto H
PROVIDER: S-EPMC2912359 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Yamamoto Hideaki H Koga Hiroshi H Katoh Yohei Y Takahashi Senye S Nakayama Kazuhisa K Shin Hye-Won HW
Molecular biology of the cell 20100609 15
The small GTPase Rab14 localizes to early endosomes and the trans-Golgi network, but its cellular functions on endosomes and its functional relationship with other endosomal Rab proteins are poorly understood. Here, we report that Rab14 binds in a GTP-dependent manner to RUFY1/Rabip4, which had been originally identified as a Rab4 effector. Rab14 colocalizes well with Rab4 on peripheral endosomes. Depletion of Rab14, but not Rab4, causes dissociation of RUFY1 from endosomal membranes. Coexpressi ...[more]