Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC2912429 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Zhang Yandong Y Danishefsky Samuel J SJ
Journal of the American Chemical Society 20100701 28
The total synthesis of the highly degraded steroidal natural product, aplykurodinone-1 (1), has been accomplished. Key features include a one-flask hydrolysis/retro-aldol/iodolactonization sequence to excise the C(8) hydroxymethylene functionality with retention of stereochemistry and the stereoselective installation of the C(13) methyl group through hydrogenation with homogeneous catalyst. ...[more]