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Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia.


ABSTRACT: Universal childhood hepatitis B vaccination was introduced in Indonesia in 1997; by 2008, coverage was estimated to be 78%. This study aimed to investigate the serologic status and virologic characteristics of hepatitis B virus (HBV) among the children in East Java. A total of 229 healthy children born during 1994-1999 were enrolled in this study. Overall, 3.1% were positive for hepatitis B surface antigen (HBsAg) and 23.6% were positive for antibody to HBsAg (anti-HBs). HBV DNA was detected in 5 of 222 HBsAg-negative carriers, which were suggested to be cases of occult HBV infection. A single amino substitution (T126I) in the S region was frequently found. HBV infection remains endemic, and the prevalence of anti-HBs remains insufficient among children in East Java, Indonesia.

SUBMITTER: Utsumi T 

PROVIDER: S-EPMC2912598 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia.

Utsumi Takako T   Yano Yoshihiko Y   Lusida Maria Inge MI   Amin Mochamad M   Soetjipto   Hotta Hak H   Hayashi Yoshitake Y  

The American journal of tropical medicine and hygiene 20100701 1


Universal childhood hepatitis B vaccination was introduced in Indonesia in 1997; by 2008, coverage was estimated to be 78%. This study aimed to investigate the serologic status and virologic characteristics of hepatitis B virus (HBV) among the children in East Java. A total of 229 healthy children born during 1994-1999 were enrolled in this study. Overall, 3.1% were positive for hepatitis B surface antigen (HBsAg) and 23.6% were positive for antibody to HBsAg (anti-HBs). HBV DNA was detected in  ...[more]

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