Ontology highlight
ABSTRACT:
SUBMITTER: Benford ML
PROVIDER: S-EPMC2912864 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Benford Marnita L ML VanCleave Tiva T TT Lavender Nicole A NA Kittles Rick A RA Kidd LaCreis R LR
BMC cancer 20100628
<h4>Background</h4>Human chromosome 8q24 has been implicated in prostate tumorigenesis.<h4>Methods</h4>Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR).<h4>Results</h4>Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk ...[more]