Ontology highlight
ABSTRACT:
SUBMITTER: Han Y
PROVIDER: S-EPMC4948565 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Han Ying Y Rand Kristin A KA Hazelett Dennis J DJ Ingles Sue A SA Kittles Rick A RA Strom Sara S SS Rybicki Benjamin A BA Nemesure Barbara B Isaacs William B WB Stanford Janet L JL Zheng Wei W Schumacher Fredrick R FR Berndt Sonja I SI Wang Zhaoming Z Xu Jianfeng J Rohland Nadin N Reich David D Tandon Arti A Pasaniuc Bogdan B Allen Alex A Quinque Dominique D Mallick Swapan S Notani Dimple D Rosenfeld Michael G MG Jayani Ranveer Singh RS Kolb Suzanne S Gapstur Susan M SM Stevens Victoria L VL Pettaway Curtis A CA Yeboah Edward D ED Tettey Yao Y Biritwum Richard B RB Adjei Andrew A AA Tay Evelyn E Truelove Ann A Niwa Shelley S Chokkalingam Anand P AP John Esther M EM Murphy Adam B AB Signorello Lisa B LB Carpten John J Leske M Cristina MC Wu Suh-Yuh SY Hennis Anslem J M AJM Neslund-Dudas Christine C Hsing Ann W AW Chu Lisa L Goodman Phyllis J PJ Klein Eric A EA Zheng S Lilly SL Witte John S JS Casey Graham G Lubwama Alex A Pooler Loreall C LC Sheng Xin X Coetzee Gerhard A GA Cook Michael B MB Chanock Stephen J SJ Stram Daniel O DO Watya Stephen S Blot William J WJ Conti David V DV Henderson Brian E BE Haiman Christopher A CA
Journal of the National Cancer Institute 20160127 7
The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8-128.8Mb) in search of novel associations with common and rare variation in 4853 prostate cancer case patients and 4678 control subjects of African ancestry. All statistical tests were two-sided. We identified three independent associations at P values of less than 5.00×10(-8), all of which were replicated in studies from Gh ...[more]