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PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica.


ABSTRACT: We report an interaction between poxA, encoding a paralog of lysyl tRNA-synthetase, and the closely linked yjeK gene, encoding a putative 2,3-beta-lysine aminomutase, that is critical for virulence and stress resistance in Salmonella enterica. Salmonella poxA and yjeK mutants share extensive phenotypic pleiotropy, including attenuated virulence in mice, an increased ability to respire under nutrient-limiting conditions, hypersusceptibility to a variety of diverse growth inhibitors, and altered expression of multiple proteins, including several encoded on the SPI-1 pathogenicity island. PoxA mediates posttranslational modification of bacterial elongation factor P (EF-P), analogous to the modification of the eukaryotic EF-P homolog, eIF5A, with hypusine. The modification of EF-P is a mechanism of regulation whereby PoxA acts as an aminoacyl-tRNA synthetase that attaches an amino acid to a protein resembling tRNA rather than to a tRNA.

SUBMITTER: Navarre WW 

PROVIDER: S-EPMC2913146 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica.

Navarre William Wiley WW   Zou S Betty SB   Roy Hervé H   Xie Jinglin Lucy JL   Savchenko Alexei A   Singer Alexander A   Edvokimova Elena E   Prost Lynne R LR   Kumar Runjun R   Ibba Michael M   Fang Ferric C FC  

Molecular cell 20100701 2


We report an interaction between poxA, encoding a paralog of lysyl tRNA-synthetase, and the closely linked yjeK gene, encoding a putative 2,3-beta-lysine aminomutase, that is critical for virulence and stress resistance in Salmonella enterica. Salmonella poxA and yjeK mutants share extensive phenotypic pleiotropy, including attenuated virulence in mice, an increased ability to respire under nutrient-limiting conditions, hypersusceptibility to a variety of diverse growth inhibitors, and altered e  ...[more]

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