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Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs.

ABSTRACT: The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels-Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity.

SUBMITTER: Burai R

PROVIDER: S-EPMC2913306 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs.

Burai Ritwik R Ramesh Chinnasamy C Shorty Marvin M Curpan Ramona R Bologa Cristian C Sklar Larry A LA Oprea Tudor T Prossnitz Eric R ER Arterburn Jeffrey B JB

Organic & biomolecular chemistry 20100316 9

The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels-Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity. ...[more]

PMID: 20401403

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