Ontology highlight
ABSTRACT:
SUBMITTER: Amorim MJ
PROVIDER: S-EPMC2913401 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Amorim Maria J MJ Cotobal Cristina C Duncan Caia C Mata Juan J
Molecular systems biology 20100601
The function of transcription in dynamic gene expression programs has been extensively studied, but little is known about how it is integrated with RNA turnover at the genome-wide level. We investigated these questions using the meiotic gene expression program of Schizosaccharomyces pombe. We identified over 80 transcripts that co-purify with the meiotic-specific Meu5p RNA-binding protein. Their levels and half-lives were reduced in meu5 mutants, demonstrating that Meu5p stabilizes its targets. ...[more]