Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
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ABSTRACT:
SUBMITTER: Conde L
PROVIDER: S-EPMC2913472 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
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Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
Conde Lucia L Halperin Eran E Akers Nicholas K NK Brown Kevin M KM Smedby Karin E KE Rothman Nathaniel N Nieters Alexandra A Slager Susan L SL Brooks-Wilson Angela A Agana Luz L Riby Jacques J Liu Jianjun J Adami Hans-Olov HO Darabi Hatef H Hjalgrim Henrik H Low Hui-Qi HQ Humphreys Keith K Melbye Mads M Chang Ellen T ET Glimelius Bengt B Cozen Wendy W Davis Scott S Hartge Patricia P Morton Lindsay M LM Schenk Maryjean M Wang Sophia S SS Armstrong Bruce B Kricker Anne A Milliken Sam S Purdue Mark P MP Vajdic Claire M CM Boyle Peter P Lan Qing Q Zahm Shelia H SH Zhang Yawei Y Zheng Tongzhang T Becker Nikolaus N Benavente Yolanda Y Boffetta Paolo P Brennan Paul P Butterbach Katja K Cocco Pierluigi P Foretova Lenka L Maynadié Marc M de Sanjosé Silvia S Staines Anthony A Spinelli John J JJ Achenbach Sara J SJ Call Timothy G TG Camp Nicola J NJ Glenn Martha M Caporaso Neil E NE Cerhan James R JR Cunningham Julie M JM Goldin Lynn R LR Hanson Curtis A CA Kay Neil E NE Lanasa Mark C MC Leis Jose F JF Marti Gerald E GE Rabe Kari G KG Rassenti Laura Z LZ Spector Logan G LG Strom Sara S SS Vachon Celine M CM Weinberg J Brice JB Holly Elizabeth A EA Chanock Stephen S Smith Martyn T MT Bracci Paige M PM Skibola Christine F CF
Nature genetics 20100718 8
To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between ...[more]
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