Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.

ABSTRACT: Background:Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31. Methods:To identify a susceptibility locus for meningioma, we conducted a meta-analysis of 2 GWAS, imputed using a merged reference panel from the 1000 Genomes Project and UK10K data, with validation in 2 independent sample series totaling 2138 cases and 12081 controls. Results:We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges. Conclusions:This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma.

SUBMITTER: Claus EB 

PROVIDER: S-EPMC6176799 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature