Ontology highlight
ABSTRACT:
SUBMITTER: Ortiz-Estevez M
PROVIDER: S-EPMC2913655 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Ortiz-Estevez Maria M Bengtsson Henrik H Rubio Angel A
Bioinformatics (Oxford, England) 20100606 15
<h4>Motivation</h4>Current algorithms for estimating DNA copy numbers (CNs) borrow concepts from gene expression analysis methods. However, single nucleotide polymorphism (SNP) arrays have special characteristics that, if taken into account, can improve the overall performance. For example, cross hybridization between alleles occurs in SNP probe pairs. In addition, most of the current CN methods are focused on total CNs, while it has been shown that allele-specific CNs are of paramount importanc ...[more]