Ontology highlight
ABSTRACT:
SUBMITTER: Stamatoyannopoulos JA
PROVIDER: S-EPMC2914101 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Stamatoyannopoulos John A JA Adzhubei Ivan I Thurman Robert E RE Kryukov Gregory V GV Mirkin Sergei M SM Sunyaev Shamil R SR
Nature genetics 20090315 4
Eukaryotic DNA replication is highly stratified, with different genomic regions shown to replicate at characteristic times during S phase. Here we observe that mutation rate, as reflected in recent evolutionary divergence and human nucleotide diversity, is markedly increased in later-replicating regions of the human genome. All classes of substitutions are affected, suggesting a generalized mechanism involving replication time-dependent DNA damage. This correlation between mutation rate and regi ...[more]