Ontology highlight
ABSTRACT:
SUBMITTER: Koren A
PROVIDER: S-EPMC4359889 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Cell 20141113 5
Genomic DNA replicates in a choreographed temporal order that impacts the distribution of mutations along the genome. We show here that DNA replication timing is shaped by genetic polymorphisms that act in cis upon megabase-scale DNA segments. In genome sequences from proliferating cells, read depth along chromosomes reflected DNA replication activity in those cells. We used this relationship to analyze variation in replication timing among 161 individuals sequenced by the 1000 Genomes Project. ...[more]