Ontology highlight
ABSTRACT:
SUBMITTER: Ying H
PROVIDER: S-EPMC2915549 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Ying Haiyan H Yang Lifen L Qiao Guilin G Li Zhenping Z Zhang Li L Yin Fei F Xie Dong D Zhang Jian J
Journal of immunology (Baltimore, Md. : 1950) 20100702 3
Th cells that produce IL-17 (Th17 cells) are a distinct subset of Th cells implicated in several autoimmune diseases. Although CD28-B7 interaction has been shown to be involved in Th17 differentiation in vitro, the role of CTLA-4 in controlling Th17 development is completely unknown. We report in this paper that blocking the CTLA-4-B7 interaction potentiates Th17 cell differentiation in vitro and in vivo. Furthermore, blocking CTLA-4-B7 interaction in vivo confers the susceptibility of experimen ...[more]