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Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.

ABSTRACT: Th cells that produce IL-17 (Th17 cells) are a distinct subset of Th cells implicated in several autoimmune diseases. Although CD28-B7 interaction has been shown to be involved in Th17 differentiation in vitro, the role of CTLA-4 in controlling Th17 development is completely unknown. We report in this paper that blocking the CTLA-4-B7 interaction potentiates Th17 cell differentiation in vitro and in vivo. Furthermore, blocking CTLA-4-B7 interaction in vivo confers the susceptibility of experimental autoimmune myocarditis to CD28(-/-) mice or increases the severity of experimental autoimmune myocarditis in wild-type mice. The enhanced disease susceptibility is mediated by heightened Th17 responses. With these results, we are the first to demonstrate that CTLA-4-B7 interaction inhibits Th17 differentiation in vitro and in vivo and suppresses Th17-mediated autoimmunity.

SUBMITTER: Ying H

PROVIDER: S-EPMC2915549 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.

Ying Haiyan H Yang Lifen L Qiao Guilin G Li Zhenping Z Zhang Li L Yin Fei F Xie Dong D Zhang Jian J

Journal of immunology (Baltimore, Md. : 1950) 20100702 3

Th cells that produce IL-17 (Th17 cells) are a distinct subset of Th cells implicated in several autoimmune diseases. Although CD28-B7 interaction has been shown to be involved in Th17 differentiation in vitro, the role of CTLA-4 in controlling Th17 development is completely unknown. We report in this paper that blocking the CTLA-4-B7 interaction potentiates Th17 cell differentiation in vitro and in vivo. Furthermore, blocking CTLA-4-B7 interaction in vivo confers the susceptibility of experimen ...[more]

PMID: 20601598

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