Ontology highlight
ABSTRACT:
SUBMITTER: Magenau JM
PROVIDER: S-EPMC2916071 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20100317 7
The relationship between regulatory T cells (Tregs) and acute graft-versus-host disease (aGVHD) in clinical allogeneic bone marrow transplantation (BMT) recipients is not well established. We conducted a prospective analysis of peripheral blood Tregs as determined by the frequency of CD4(+)CD25(hi)FOXP3(+) lymphocytes in 215 BMT patients. Autologous BMT patients (N = 90) and allogeneic BMT patients without GVHD (N = 65) had similar Treg frequencies, whereas allogeneic patients with GVHD (N = 60) ...[more]