Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae.
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ABSTRACT:
SUBMITTER: Zahner D
PROVIDER: S-EPMC2916318 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae.
Zähner Dorothea D Zhou Xiaoliu X Chancey Scott T ST Pohl Jan J Shafer William M WM Stephens David S DS
Antimicrobial agents and chemotherapy 20100524 8
Macrolide resistance is a major concern in the treatment of Streptococcus pneumoniae. Inducible macrolide resistance in this pneumococcus is mediated by the efflux pump MefE/Mel. We show here that the human antimicrobial peptide LL-37 induces the mefE promoter and confers resistance to erythromycin and LL-37. Such induction may impact the efficacy of host defenses and of macrolide-based treatment of pneumococcal disease. ...[more]
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