Ontology highlight
ABSTRACT:
SUBMITTER: Freeman TC
PROVIDER: S-EPMC2916714 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Freeman Thomas C TC Wimley William C WC
Bioinformatics (Oxford, England) 20100610 16
<h4>Motivation</h4>Transmembrane beta-barrels (TMBBs) belong to a special structural class of proteins predominately found in the outer membranes of Gram-negative bacteria, mitochondria and chloroplasts. TMBBs are surface-exposed proteins that perform a variety of functions ranging from nutrient acquisition to osmotic regulation. These properties suggest that TMBBs have great potential for use in vaccine or drug therapy development. However, membrane proteins, such as TMBBs, are notoriously diff ...[more]