Ontology highlight
ABSTRACT:
SUBMITTER: Dietrich I
PROVIDER: S-EPMC2919025 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Journal of virology 20100616 17
A synthetic feline TRIM5-cyclophilin A fusion protein (feTRIMCyp) was generated and transduced into feline cells. feTRIMCyp was highly efficient at preventing infection with human (HIV) and feline (FIV) immunodeficiency virus pseudotypes, and feTRIMCyp-expressing cells resisted productive infection with either FIV-Fca or FIV-Pco. The restriction of FIV infection by feTRIMCyp was reversed by the cyclosporine (Cs) derivatives NIM811 and Debio-025 but less so by Cs itself. FeTRIMCyp and FIV infecti ...[more]