Ontology highlight
ABSTRACT:
SUBMITTER: Kozakov D
PROVIDER: S-EPMC2919587 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Trends in biochemical sciences 20100408 9
Structures of the influenza A virus M2 proton channel in the open conformation have been determined by X-ray crystallography, and in the closed conformation by NMR. Whereas the X-ray structure shows a single inhibitor molecule in the middle of the channel, four inhibitor molecules bind the channel's outer surface in the NMR structure. In both structures, the strongest hot spots (i.e., regions that contribute substantially to the free energy of binding any potential ligand) lie inside the pore, a ...[more]