Ontology highlight
ABSTRACT:
SUBMITTER: Hurtado A
PROVIDER: S-EPMC2920208 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Hurtado Antoni A Holmes Kelly A KA Geistlinger Timothy R TR Hutcheson Iain R IR Nicholson Robert I RI Brown Myles M Jiang Jie J Howat William J WJ Ali Simak S Carroll Jason S JS
Nature 20081112 7222
Crosstalk between the oestrogen receptor (ER) and ERBB2/HER-2 pathways has long been implicated in breast cancer aetiology and drug response, yet no direct connection at a transcriptional level has been shown. Here we show that oestrogen-ER and tamoxifen-ER complexes directly repress ERBB2 transcription by means of a cis-regulatory element within the ERBB2 gene in human cell lines. We implicate the paired box 2 gene product (PAX2), in a previously unrecognized role, as a crucial mediator of ER r ...[more]