Ontology highlight
ABSTRACT:
SUBMITTER: Xiao J
PROVIDER: S-EPMC2920259 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20100711 8
The Fic family of adenylyltransferases, defined by a core HPFx(D/E)GN(G/K)R motif, consists of over 2,700 proteins found in organisms from bacteria to humans. The immunoglobulin-binding protein A (IbpA) from the bacterial pathogen Histophilus somni contains two Fic domains that adenylylate the switch1 tyrosine residue of Rho-family GTPases, allowing the bacteria to subvert host defenses. Here we present the structure of the second Fic domain of IbpA (IbpAFic2) in complex with its substrate, Cdc4 ...[more]