Ontology highlight
ABSTRACT:
SUBMITTER: Masters SL
PROVIDER: S-EPMC2920446 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
EMBO reports 20100702 8
Reports describing the effect of interferon-gamma (IFNgamma) on interleukin-1beta (IL-1beta) production are conflicting. We resolve this controversy by showing that IFNgamma potentiates IL-1beta release from human cells, but transiently inhibits the production of IL-1beta from mouse cells. Release from this inhibition is dependent on suppressor of cytokine signalling 1. IL-1beta and Th17 cells are pathogenic in mouse models for autoimmune disease, which use Mycobacterium tuberculosis (MTB), in w ...[more]