Ontology highlight
ABSTRACT:
SUBMITTER: Ribot JC
PROVIDER: S-EPMC4167721 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Ribot Julie C JC deBarros Ana A Pang Dick John DJ Neves Joana F JF Peperzak Victor V Roberts Scott J SJ Girardi Michael M Borst Jannie J Hayday Adrian C AC Pennington Daniel J DJ Silva-Santos Bruno B
Nature immunology 20090308 4
The production of cytokines such as interferon-gamma and interleukin 17 by alphabeta and gammadelta T cells influences the outcome of immune responses. Here we show that most gammadelta T lymphocytes expressed the tumor necrosis factor receptor family member CD27 and secreted interferon-gamma, whereas interleukin 17 production was restricted to CD27(-) gammadelta T cells. In contrast to the apparent plasticity of alphabeta T cells, the cytokine profiles of these distinct gammadelta T cell subset ...[more]