Ontology highlight
ABSTRACT:
SUBMITTER: Abraham J
PROVIDER: S-EPMC2920743 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Abraham Jonathan J Corbett Kevin D KD Farzan Michael M Choe Hyeryun H Harrison Stephen C SC
Nature structural & molecular biology 20100307 4
New World hemorrhagic fever arenaviruses are rodent-borne agents that cause severe human disease. The GP1 subunit of the surface glycoprotein mediates cell attachment through transferrin receptor 1 (TfR1). We report the structure of Machupo virus (MACV) GP1 bound with human TfR1. Atomic details of the GP1-TfR1 interface clarify the importance of TfR1 residues implicated in New World arenavirus host specificity. Analysis of sequence variation among New World arenavirus GP1s and their host-species ...[more]