Ontology highlight
ABSTRACT:
SUBMITTER: Helguera G
PROVIDER: S-EPMC3302512 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Helguera Gustavo G Jemielity Stephanie S Abraham Jonathan J Cordo Sandra M SM Martinez M Guadalupe MG Rodríguez José A JA Bregni Carlos C Wang Jinyize J JJ Farzan Michael M Penichet Manuel L ML Candurra Nélida A NA Choe Hyeryun H
Journal of virology 20120125 7
Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, as well as replication of infectious Junín virus. Our data indicate that all NW hemorrhagic fever arenaviruses utilize a co ...[more]