Ontology highlight
ABSTRACT:
SUBMITTER: Yoo J
PROVIDER: S-EPMC2921153 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Yoo Jaehyuk J Kang Jinjoo J Lee Ha Neul HN Aguilar Berenice B Kafka Darren D Lee Sunju S Choi Inho I Lee Juneyong J Ramu Swapnika S Haas Juergen J Koh Chester J CJ Hong Young-Kwon YK
PLoS pathogens 20100812 8
Kaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells. However, we and others discovered that Kaposi's sarcoma herpes virus (KSHV) induces lymphatic reprogramming of blood vascular endothelial cells by upregulating PROX1, which functions as the master regulator for lymphatic endothelial differentiation. Here, we demonstrate that the KS ...[more]