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Transcription profiling of lymphatic endothelial cells infected with Kaposi's sacoma associated herpes virus

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE16353: The profile of cellular and KSHV microRNAs in AIDS_KS biopsies (and normal skin control biopsies) GSE16354: Infection of Lymphatic and Blood Vessel Endothelial Cells (LEC and BEC) with KSHV GSE16355: Lymphatic endothelial cells (LEC) transfected with the KSHV microRNA cluster GSE16356: Lymphatic endothelial cells (LEC) treated with a MAF-targeted siRNA Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Stephen Henderson

PROVIDER: E-GEOD-16357 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.

Hansen Amy A Henderson Stephen S Lagos Dimitrios D Nikitenko Leonid L Coulter Eve E Roberts Sinead S Gratrix Fiona F Plaisance Karlie K Renne Rolf R Bower Mark M Kellam Paul P Boshoff Chris C

Genes & development 20100101 2

Kaposi sarcoma herpesvirus (KSHV) induces transcriptional reprogramming of endothelial cells. In particular, KSHV-infected lymphatic endothelial cells (LECs) show an up-regulation of genes associated with blood vessel endothelial cells (BECs). Consequently, KSHV-infected tumor cells in Kaposi sarcoma are poorly differentiated endothelial cells, expressing markers of both LECs and BECs. MicroRNAs (miRNAs) are short noncoding RNA molecules that act post-transcriptionally to negatively regulate gen ...[more]

PMID: 20080955

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Transcription profiling of human lymphatic edothelial cells transfected with the KSHV microRNA cluster

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