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Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.

ABSTRACT: Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack. The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (P

SUBMITTER: Petukhova L

PROVIDER: S-EPMC2921172 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.

Petukhova Lynn L Duvic Madeleine M Hordinsky Maria M Norris David D Price Vera V Shimomura Yutaka Y Kim Hyunmi H Singh Pallavi P Lee Annette A Chen Wei V WV Meyer Katja C KC Paus Ralf R Jahoda Colin A B CA Amos Christopher I CI Gregersen Peter K PK Christiano Angela M AM

Nature 20100701 7302

Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack. The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (P <or= 5 x 10(-7)). Here we show an association with ...[more]

PMID: 20596022

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