Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
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ABSTRACT:
SUBMITTER: Law PJ
PROVIDER: S-EPMC5303820 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
Law Philip J PJ Berndt Sonja I SI Speedy Helen E HE Camp Nicola J NJ Sava Georgina P GP Skibola Christine F CF Holroyd Amy A Joseph Vijai V Sunter Nicola J NJ Nieters Alexandra A Bea Silvia S Monnereau Alain A Martin-Garcia David D Goldin Lynn R LR Clot Guillem G Teras Lauren R LR Quintela Inés I Birmann Brenda M BM Jayne Sandrine S Cozen Wendy W Majid Aneela A Smedby Karin E KE Lan Qing Q Dearden Claire C Brooks-Wilson Angela R AR Hall Andrew G AG Purdue Mark P MP Mainou-Fowler Tryfonia T Vajdic Claire M CM Jackson Graham H GH Cocco Pierluigi P Marr Helen H Zhang Yawei Y Zheng Tongzhang T Giles Graham G GG Lawrence Charles C Call Timothy G TG Liebow Mark M Melbye Mads M Glimelius Bengt B Mansouri Larry L Glenn Martha M Curtin Karen K Diver W Ryan WR Link Brian K BK Conde Lucia L Bracci Paige M PM Holly Elizabeth A EA Jackson Rebecca D RD Tinker Lesley F LF Benavente Yolanda Y Boffetta Paolo P Brennan Paul P Maynadie Marc M McKay James J Albanes Demetrius D Weinstein Stephanie S Wang Zhaoming Z Caporaso Neil E NE Morton Lindsay M LM Severson Richard K RK Riboli Elio E Vineis Paolo P Vermeulen Roel C H RC Southey Melissa C MC Milne Roger L RL Clavel Jacqueline J Topka Sabine S Spinelli John J JJ Kraft Peter P Ennas Maria Grazia MG Summerfield Geoffrey G Ferri Giovanni M GM Harris Robert J RJ Miligi Lucia L Pettitt Andrew R AR North Kari E KE Allsup David J DJ Fraumeni Joseph F JF Bailey James R JR Offit Kenneth K Pratt Guy G Hjalgrim Henrik H Pepper Chris C Chanock Stephen J SJ Fegan Chris C Rosenquist Richard R de Sanjose Silvia S Carracedo Angel A Dyer Martin J S MJ Catovsky Daniel D Campo Elias E Cerhan James R JR Allan James M JM Rothman Nathanial N Houlston Richard R Slager Susan S
Nature communications 20170206
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10<sup>-13</sup>), 1q42.13 (rs41271473, P=1.06 × 10<sup>-10</sup>), 4q24 (rs71597109, P=1.37 ...[more]
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