Ontology highlight
ABSTRACT:
SUBMITTER: Brent D
PROVIDER: S-EPMC2921883 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Brent David D Melhem Nadine N Turecki Gustavo G
Pharmacogenomics 20100601 6
Pharmacogenomic studies of antidepressant treatment-emergent suicidal events in depressed patients report associations with polymorphisms in genes involved in transcription (CREB1), neuroprotection (BDNF and NTRK2), glutamatergic and noradrenergic neurotransmission (GRIA3, GRIK2 and ADRA2A), the stress and inflammatory responses (FKBP5 and IL28RA), and the synthesis of glycoproteins (PAPLN). Nearly all of the reported events in these studies were modest one-time increases in suicidal ideation. I ...[more]