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Macromolecular and dendrimer-based magnetic resonance contrast agents.

ABSTRACT: Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an assessment of function or molecular expression in tandem with anatomic detail. Over the last 20-25 years, a number of gadolinium-based MR contrast agents have been developed to enhance signal by altering proton relaxation properties. This review explores a range of these agents from small molecule chelates, such as Gd-DTPA and Gd-DOTA, to macromolecular structures composed of albumin, polylysine, polysaccharides (dextran, inulin, starch), poly(ethylene glycol), copolymers of cystamine and cystine with GD-DTPA, and various dendritic structures based on polyamidoamine and polylysine (Gadomers). The synthesis, structure, biodistribution, and targeting of dendrimer-based MR contrast agents are also discussed.

SUBMITTER: Bumb A

PROVIDER: S-EPMC2922462 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Macromolecular and dendrimer-based magnetic resonance contrast agents.

Bumb Ambika A Brechbiel Martin W MW Choyke Peter P

Acta radiologica (Stockholm, Sweden : 1987) 20100901 7

Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an assessment of function or molecular expression in tandem with anatomic detail. Over the last 20-25 years, a number of gadolinium-based MR contrast agents have been developed to enhance signal by altering proton relaxation properties. This review explores a range of these agents from small molecule chelates, such as Gd-DTPA and Gd-DOTA, to macromolecular structures composed of albumin, polylysine, polysaccharides ...[more]

PMID: 20590365

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