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Formation of gadolinium-ferritin from clinical magnetic resonance contrast agents.

ABSTRACT: Gadolinium deposition in the brain following administration of gadolinium-based contrast agents (GBCAs) has led to health concerns. We show that some clinical GBCAs form Gd³⁺-ferritin nanoparticles at (sub)nanomolar concentrations of Gd³⁺ under physiological conditions. We describe their structure at atomic resolution and discuss potential relevance for clinical MRI.

SUBMITTER: Neburkova J

PROVIDER: S-EPMC9417687 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Formation of gadolinium-ferritin from clinical magnetic resonance contrast agents.

Neburkova Jitka J Rulseh Aaron M AM Chang Shery L Y SLY Raabova Helena H Vejpravova Jana J Dracinsky Martin M Tarabek Jan J Kotek Jan J Pingle Mohan M Majer Pavel P Vymazal Josef J Cigler Petr P

Nanoscale advances 20200831 12

Gadolinium deposition in the brain following administration of gadolinium-based contrast agents (GBCAs) has led to health concerns. We show that some clinical GBCAs form Gd<sup>3+</sup>-ferritin nanoparticles at (sub)nanomolar concentrations of Gd<sup>3+</sup> under physiological conditions. We describe their structure at atomic resolution and discuss potential relevance for clinical MRI. ...[more]

PMID: 36133872

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