Ontology highlight
ABSTRACT:
SUBMITTER: Henderson WR
PROVIDER: S-EPMC2922550 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Henderson William R WR Chi Emil Y EY Ye Xin X Nguyen Cu C Tien Ying-tzang YT Zhou Beiyun B Borok Zea Z Knight Darryl A DA Kahn Michael M
Proceedings of the National Academy of Sciences of the United States of America 20100721 32
Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia is a ravaging condition of progressive lung scarring and destruction. Anti-inflammatory therapies including corticosteroids have limited efficacy in this ultimately fatal disorder. An important unmet need is to identify new agents that interact with key molecular pathways involved in the pathogenesis of pulmonary fibrosis to prevent progression or reverse fibrosis in these patients. Because aberrant activation of the Wnt/beta-caten ...[more]