Ontology highlight
ABSTRACT:
SUBMITTER: Lee YY
PROVIDER: S-EPMC3679460 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Lee Y Y YY Moujalled D D Doerflinger M M Gangoda L L Weston R R Rahimi A A de Alboran I I Herold M M Bouillet P P Xu Q Q Gao X X Du X-J XJ Puthalakath H H
Cell death and differentiation 20130412 7
Catecholamines regulate the β-adrenoceptor/cyclic AMP-regulated protein kinase A (cAMP/PKA) pathway. Deregulation of this pathway can cause apoptotic cell death and is implicated in a range of human diseases, such as neuronal loss during aging, cardiomyopathy and septic shock. The molecular mechanism of this process is, however, only poorly understood. Here we demonstrate that the β-adrenoceptor/cAMP/PKA pathway triggers apoptosis through the transcriptional induction of the pro-apoptotic BH3-on ...[more]