Ontology highlight
ABSTRACT:
SUBMITTER: Cotner-Gohara E
PROVIDER: S-EPMC2922849 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Cotner-Gohara Elizabeth E Kim In-Kwon IK Hammel Michal M Tainer John A JA Tomkinson Alan E AE Ellenberger Tom T
Biochemistry 20100701 29
Human DNA ligase III has essential functions in nuclear and mitochondrial DNA replication and repair and contains a PARP-like zinc finger (ZnF) that increases the extent of DNA nick joining and intermolecular DNA ligation, yet the bases for ligase III specificity and structural variation among human ligases are not understood. Here combined crystal structure and small-angle X-ray scattering results reveal dynamic switching between two nick-binding components of ligase III: the ZnF-DNA binding do ...[more]