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Layer I as a putative neurogenic niche in young adult guinea pig cerebrum.

ABSTRACT: A considerable number of cells expressing typical immature neuronal markers including doublecortin (DCX+) are present around layer II in the cerebral cortex of young and adult guinea pigs and other larger mammals, and their origin and biological implication await further characterization. We show here in young adult guinea pigs that these DCX+ cells are accompanied by in situ cell division around the superficial cortical layers mostly in layer I, but they co-express proliferating cell nuclear antigen (PCNA) and an early neuronal fate determining factor, PAX6. A small number of these DCX+ cells also colocalize with BrdU following administration of this mitotic indicator. Cranial X-ray irradiation causes a decline of DCX+ cells around layer II, and novel environmental exploration induces c-Fos expression among these cells in several neocortical areas. Together, these data are compatible with a notion that DCX+ cortical neurons around layer II might derive from proliferable neuronal precursors around layer I in young adult guinea pig cerebrum, and that these cells might be modulated by experience under physiological conditions.

SUBMITTER: Xiong K

PROVIDER: S-EPMC2923265 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Layer I as a putative neurogenic niche in young adult guinea pig cerebrum.

Xiong Kun K Cai Yan Y Zhang Xue-Mei XM Huang Ju-Fang JF Liu Zhong-Yu ZY Fu Guang-Ming GM Feng Jia-Chun JC Clough Richard W RW Patrylo Peter R PR Luo Xue-Gang XG Hu Chun-Hong CH Yan Xiao-Xin XX

Molecular and cellular neurosciences 20100621 2

A considerable number of cells expressing typical immature neuronal markers including doublecortin (DCX+) are present around layer II in the cerebral cortex of young and adult guinea pigs and other larger mammals, and their origin and biological implication await further characterization. We show here in young adult guinea pigs that these DCX+ cells are accompanied by in situ cell division around the superficial cortical layers mostly in layer I, but they co-express proliferating cell nuclear an ...[more]

PMID: 20599617

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Dataset Information

Layer I as a putative neurogenic niche in young adult guinea pig cerebrum.

Publications

Layer I as a putative neurogenic niche in young adult guinea pig cerebrum.

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