Ontology highlight
ABSTRACT:
SUBMITTER: Lee M
PROVIDER: S-EPMC2923472 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Lee Minhee M Gubernator Niko G NG Sulzer David D Sames Dalibor D
Journal of the American Chemical Society 20100701 26
We introduce pH-responsive fluorescent false neurotransmitters (pH-responsive FFNs) as novel probes that act as vesicular monoamine transporter (VMAT) substrates and ratiometric fluorescent pH sensors. The development of these agents was achieved by systematic molecular design that integrated several structural elements, including the aminoethyl group (VMAT recognition), halogenated hydroxy-coumarin core (ratiometric optical pH sensing in the desired pH range), and N- or C-alkylation (modulation ...[more]