Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC2924098 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Liu Jun J Luo Xiao-Ju XJ Xiong An-Wen AW Zhang Zeng-di ZD Yue Shen S Zhu Ming-Sheng MS Cheng Steven Y SY
The Journal of biological chemistry 20100609 34
Vertebrate muscle differentiation is coordinated by an intricate network of transcription factors requiring proliferating myogenic precursors to withdraw irreversibly from the cell cycle. Recent studies have implicated a large number of microRNAs exerting another layer of control in many aspects of muscle differentiation. By annealing to short recognition sequences in the 3'-untranslated region, microRNAs attenuate target gene expression through translation repression or mRNA degradation. Here, ...[more]