Ontology highlight
ABSTRACT:
SUBMITTER: Ranjit DK
PROVIDER: S-EPMC2924435 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Ranjit Dev K DK Rideout Marc C MC Nefzi Adel A Ostresh John M JM Pinilla Clemencia C Segall Anca M AM
Bioorganic & medicinal chemistry letters 20100608 15
Our lab has isolated hexameric peptides that are structure-selective ligands of Holliday junctions (HJ), central intermediates of several DNA recombination reactions. One of the most potent of these inhibitors, WRWYCR, has shown antibacterial activity in part due to its inhibition of DNA repair proteins. To increase the therapeutic potential of these inhibitors, we searched for small molecule inhibitors with similar activities. We screened 11 small molecule libraries comprising over nine million ...[more]