Ontology highlight
ABSTRACT:
SUBMITTER: Mwakwari SC
PROVIDER: S-EPMC2924451 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20100801 16
Inhibition of histone deacetylase (HDAC) function is a validated therapeutic strategy for cancer treatment. Of the several structurally distinct small molecule histone deacetylase inhibitors (HDACi) reported, macrocyclic depsipeptides possess the most complex cap groups and have demonstrated excellent HDAC inhibition potency and isoform selectivity. Unfortunately, the development of macrocyclic depsipeptides has been hampered in part because of development problems characteristic of large peptid ...[more]