Ontology highlight
ABSTRACT:
SUBMITTER: Tapadar S
PROVIDER: S-EPMC4685012 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Tapadar Subhasish S Fathi Shaghayegh S Raji Idris I Omesiete Wilson W Kornacki James R JR Mwakwari Sandra C SC Miyata Masanori M Mitsutake Kazunori K Li Jian-Dong JD Mrksich Milan M Oyelere Adegboyega K AK
Bioorganic & medicinal chemistry 20151102 24
Inhibition of the enzymatic activity of histone deacetylase (HDAC) is a promising therapeutic strategy for cancer treatment and several distinct small molecule histone deacetylase inhibitors (HDACi) have been reported. We have previously identified a new class of non-peptide macrocyclic HDACi derived from 14- and 15-membered macrolide skeletons. In these HDACi, the macrocyclic ring is linked to the zinc chelating hydroxamate moiety through a para-substituted aryl-triazole cap group. To further d ...[more]