Ontology highlight
ABSTRACT:
SUBMITTER: Rozowsky J
PROVIDER: S-EPMC2924752 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Rozowsky Joel J Euskirchen Ghia G Auerbach Raymond K RK Zhang Zhengdong D ZD Gibson Theodore T Bjornson Robert R Carriero Nicholas N Snyder Michael M Gerstein Mark B MB
Nature biotechnology 20090104 1
Chromatin immunoprecipitation (ChIP) followed by tag sequencing (ChIP-seq) using high-throughput next-generation instrumentation is fast, replacing chromatin immunoprecipitation followed by genome tiling array analysis (ChIP-chip) as the preferred approach for mapping of sites of transcription-factor binding and chromatin modification. Using two deeply sequenced data sets for human RNA polymerase II and STAT1, each with matching input-DNA controls, we describe a general scoring approach to addre ...[more]