Ontology highlight
ABSTRACT:
SUBMITTER: Mohrin M
PROVIDER: S-EPMC2924905 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Mohrin Mary M Bourke Emer E Alexander David D Warr Matthew R MR Barry-Holson Keegan K Le Beau Michelle M MM Morrison Ciaran G CG Passegué Emmanuelle E
Cell stem cell 20100708 2
Most adult stem cells, including hematopoietic stem cells (HSCs), are maintained in a quiescent or resting state in vivo. Quiescence is widely considered to be an essential protective mechanism for stem cells that minimizes endogenous stress caused by cellular respiration and DNA replication. We demonstrate that HSC quiescence can also have detrimental effects. We found that HSCs have unique cell-intrinsic mechanisms ensuring their survival in response to ionizing irradiation (IR), which include ...[more]