Ontology highlight
ABSTRACT:
SUBMITTER: Zhang N
PROVIDER: S-EPMC2925178 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Developmental cell 20100701 1
The conserved Hippo signaling pathway regulates organ size in Drosophila and mammals. While a core kinase cascade leading from the protein kinase Hippo (Hpo) (Mst1 and Mst2 in mammals) to the transcription coactivator Yorkie (Yki) (YAP in mammals) has been established, upstream regulators of the Hippo kinase cascade are less well defined, especially in mammals. Using conditional knockout mice, we demonstrate that the Merlin/NF2 tumor suppressor and the YAP oncoprotein function antagonistically t ...[more]