Ontology highlight
ABSTRACT:
SUBMITTER: Gladden AB
PROVIDER: S-EPMC3033574 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Gladden Andrew B AB Hebert Alan M AM Schneeberger Eveline E EE McClatchey Andrea I AI
Developmental cell 20101101 5
The neurofibromatosis type 2 (NF2) tumor suppressor, Merlin, is a FERM (Four point one, Ezrin, Radixin, Moesin) domain-containing protein whose loss results in defective morphogenesis and tumorigenesis in multiple tissues. Like the closely related ERM proteins (Ezrin, Radixin, and Moesin), Merlin may organize the plasma membrane by assembling membrane protein complexes and linking them to the cortical actin cytoskeleton. We previously found that Merlin is a critical mediator of contact-dependent ...[more]