Ontology highlight
ABSTRACT:
SUBMITTER: Schraufstatter IU
PROVIDER: S-EPMC2925301 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Schraufstatter Ingrid U IU DiScipio Richard G RG Khaldoyanidi Sophia K SK
Journal of stem cells 20090101 4
The efficient migration of mesenchymal stem cells (MSCs) to diseased tissues is required for the fulfillment of their regenerative potential. Recruitment of circulating cells into the damaged tissues is regulated by a complex network, which includes the non-neural cholinergic system. We found that human MSCs (hMSCs) express nicotinic acetylcholine receptor subunits alpha 7, beta 2 and beta 4. The receptor agonist nicotine caused calcium (Ca(++)) influx into hMSCs suggesting that the calcium ion ...[more]