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A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides.

ABSTRACT: A method by which to accomplish formal threonine ligation has been developed. The method accomplishes ligations of two peptide domains. We have also demonstrated the ability to successfully ligate two independent glycopeptide domains.

SUBMITTER: Chen J

PROVIDER: S-EPMC2925322 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides.

Chen Jin J Wang Ping P Zhu Jianglong J Wan Qian Q Danishefsky Samuel J SJ

Tetrahedron 20100301 13

A method by which to accomplish formal threonine ligation has been developed. The method accomplishes ligations of two peptide domains. We have also demonstrated the ability to successfully ligate two independent glycopeptide domains. ...[more]

PMID: 20798898

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