Ontology highlight
ABSTRACT:
SUBMITTER: Sardar MYR
PROVIDER: S-EPMC5682196 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Carbohydrate research 20171010
Lewis<sup>X</sup> (Le<sup>X</sup>) is a branched trisaccharide Galβ1→4(Fucα1→3)GlcNAc that is expressed on many cell surface glycoproteins and plays critical roles in innate and adaptive immune responses. However, efficient synthesis of glycopeptides bearing Le<sup>X</sup> remains a major limitation for structure-function studies of the Le<sup>X</sup> determinant. Here we report a total synthesis of a Le<sup>X</sup> pentasaccharide 1 using a regioselective 1-benzenesulfinyl piperidine/triflic an ...[more]