Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC2925643 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Wang Yuhua Y Mangipudi Sriramchandra Sastry SS Canine Brenda F BF Hatefi Arash A
Journal of controlled release : official journal of the Controlled Release Society 20090318 1
Designer biomimetic vectors are genetically engineered biomacromolecules that are designed to mimic viral characteristics in order to overcome the cellular barriers associated with the targeted gene transfer. The vector in this study was genetically engineered to contain at precise locations: a) four tandem repeating units of N-terminal domain of histone H2A to condense DNA into stable nanosize particles suitable for cellular uptake, b) a model targeting motif to target HER2 and enhance internal ...[more]